An D’Huys studied at Sint-Lukas Institute Brussels and fashion at the Royal Academy of Fine Arts in Antwerp she was part of the design team for Ann Demeulemeester for over 12 years.

Recent productions include Hedda Gabler at the National Theatre; Lazarus in London and at New York Theatre Workshop; The Damned for Comédie-Française at Avignon and Paris; Husbands and Wives, The Things thatpass, Othello, Opening Night, Medea, The Fountainhead, Antigone and Kings of War for Toneelgroep Amsterdam; A View from the Bridge at the Young Vic, in the West End and on Broadway; The Three Sisters, Poquelin, Summerfolk and The Cherry Orchard at TG STAN Antwerp; The Misanthrope at Schaubühne Berlin; Die Walküre, Siegfried and Götterdämmerung for Flanders Opera; and Quartet, Bitches Brew and Cassandra for Rosas Ballet Brussels.

She also designed costumes for several film productions including Toto le héros (Jaco van Dormael) and Rosie (Patrice Toye).