Wealthy Mississippi plantation owner Big Daddy Pollitt, unaware that he's dying of cancer and disturbed by the strained and childless marriage of his favored alcoholic son Brick and his other son, Gooper, whose wife is about to bring forth another in the endless line of little "no-neck monsters," celebrates his sixty-fifth birthday with his family. Brick's wife, Maggie, beautiful and desirable, tries unsuccessfully to coax her husband away from the bottle, while alternately enticing him and taunting him about his obsession with his deceased best friend and the guilt about their relationship. The seamy tensions reach a climax when the truth of Big Daddy's health is revealed, and he and Brick manage to resolve their differences.